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To clean your motherboard first unplugs
your system power from the electrical outlet.
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Using the screwdriver remove the side
covers of your computer case and put them to one side.
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Check all data and power cables
connections. Inspect all motherboard PCI and AGP slots.
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Remove all add-on card of your motherboard
for example RAM, modem, VGA, sound card and LAN card.
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Now blow the air around all the
motherboard sides and keeping away your blower nozzle 4 to 5
inches away from main board components. You can use vacuum
cleaner also for this purpose but compressed air is the better
solution to clean a system.
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At the end assemble back all cards, cables
and side covers of your system.
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I recommend you doing this after every
three months if you want to save your system life.